What Is the Clinical Impact of the Genetic Polymorphism Observed with the Effectiveness of some P2Y12 Inhibitors?

August 3, 2021
The association of genetic polymorphisms and P2Y12 inhibitors in regards to efficacy for patients with ischemic stroke or transient ischemic attack (TIA) remains controversial. Drs. Deepak Bhatt of Brigham and Women’s Hospital and Natalie Kreitzer of the University of Cincinnati discuss key perspectives from a neurocritical, emergency medicine, and stroke perspective related to this important area of medicine.
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Keys to the Neurologic Exam From a Stroke Neurologist Who Trains Non-Neurologists to Be Stroke Doctors

June 15, 2021
Ever wonder how a world renowned stroke neurologist teaches the stroke exam? Listen in to learn the foundations of the neurologic exam and strategies for efficiently identifying deficits in stroke patients.
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CT Angiography - What Should the Rest of Us Know?

June 8, 2021
CT Angiography of the head and neck has become a standard in the Emergency Department as part of the initial workup of a patient with a suspected stroke, but they are challenging to interpret.
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Tips and Tricks for Posterior Circulation Stroke Identification

June 1, 2021
The posterior circulation is the source of controversy and challenges in the management of acute stroke patients. Listen to a neurointensivist and interventional stroke physician talk to an emergency physician about the posterior circulation patients. Acute dizziness and vertigo can be separated clinically and Dr. Smith teaches us how in this podcast.
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“Gaming the Conversation”: What Really Happens in Your Mind When You Are Evaluating a Patient for Acute Stroke Diagnosis and Treatment?

May 25, 2021
Learn what really happens in the mind of a stroke expert during the evaluation of an acute stroke patient. How to avoid pitfalls and how to make sure the patients you are caring for understand what is happening. Dr. Knight guides listeners through the steps to effectively diagnose and treat acute stroke patients.
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Sep 7

Why Is the Extended Window Controversial and What Happened With the FDA?

Haemin Go posted on 9/7/2021

Moderator: William A. Knight IV, MD, FACEP, FNCS
Other Participants: Stacie L. Demel, DO, PhD

The ECASS 3 trial was an RCT of IV-rtPA in the window of 3-4.5 hrs after onset of stroke symptoms. It was conducted in Europe. The European regulatory bodies have endorsed tPA for that window, but the FDA has not. Listen to two national experts in stroke discuss the trial and the meaning of the endorsement or lack thereof. This podcast is a must for acute stroke practitioners!

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2 comments on article "Why Is the Extended Window Controversial and What Happened With the FDA?"

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Ken Milne

I watched the video on ECASS-III and you mentioned the controversy in this time window. However, there was no mention of Alper et al reanalysis in the BMJ_EBM that questioned the results? Can you comment? https://ebm.bmj.com/content/25/5/168


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Ken Milne

Here was some of our feedback on Alper et al https://ebm.bmj.com/content/early/2020/08/10/bmjebm-2020-111517

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