Why Is the Extended Window Controversial and What Happened With the FDA?

September 7, 2021

Ever wonder why the FDA didn't approve the extended time window for tPA after ECASS3? Listen here to understand the discussion.

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Defining the SOC - Is 4.5 Hrs the Real Answer?

August 10, 2021
The standard of care can feel elusive. Listen here as Dr. Knight shares his expertise regarding the definition of the SOC in extended window therapy for tPA. It's not a simple question and Dr. Knight is the one to answer it.
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IV tPA for Acute Strokes in Patients with COVID - What Does the Limited Evidence Mean?

December 4, 2020
The incidence of acute stroke in COVID-19 patients occurs at a rate that is at least 7 times greater than the general population. Controversy about the safety and efficacy of IV-tPA remains.
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What Pitfalls Do Clinicians Face In Understanding Statistics In Acute Stroke Trials?

December 4, 2020
Statistics can illuminate or obfuscate. Clinicians need to understand acute stroke trial data and statistics in meaningful ways, but challenges abound.
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What Was Missing From the NINDS Trial?

December 4, 2020
The NINDS trial was the seminal study of IV-tPA in the treatment of acute stroke. Yet controversy still exists around the trial methodology and the interpretation of the data. Was anything missing from NINDS? Does it still resonate nearly 25 years later?
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