The Role of Real World Evidence in Driving Clinical Care for Anticoagulated Patients with Life-Threatening Bleeding

March 31, 2023
Experts in Emergency Medicine, Pharmacy, and Neurocritical Care describe the impact of real world evidence on the care of life-threatening bleeding in the anticoagulated patient. While clinical trial data remain the standard for clinicians, real world data provide important additional information on the use of a particular Repletion or Reversal therapy for these patients.
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Mar 31

The Role of Real World Evidence in Driving Clinical Care for Anticoagulated Patients with Life-Threatening Bleeding

Haemin Go posted on 3/31/2023


Moderator: W. Brian Gibler, MD, FACEP, FACC, FAHA
Other Participants: Paul P. Dobesh, PharmD, FACC, FAHA, FCCP, BCPS, BCCP; Gregory J. Fermann, MD; Natalie Kreitzer, MD, MS

In this podcast, experts in Emergency Medicine, Pharmacy, and Neurocritical Care describe important real world data which emphasize the use of specific reversal therapy for patients with life-threatening bleeding in the anticoagulated patient. These large retrospective trials describe patient care in multiple hospitals with large numbers of patients. For patients with Factor Xa-associated bleeding, real world evidence indicates that specific reversal using andexanet alfa is superior to nonspecific repletion therapy. Decreased mortality is associated with this specific reversal therapy. The clinician needs to use both clinical trial data and real world data to provide optimal patient care for the anticoagulated patient with life-threatening bleeding.


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1 comments on article "The Role of Real World Evidence in Driving Clinical Care for Anticoagulated Patients with Life-Threatening Bleeding"

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Benjamin Befeler

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