Why Is the Extended Window Controversial and What Happened With the FDA?

September 7, 2021

Ever wonder why the FDA didn't approve the extended time window for tPA after ECASS3? Listen here to understand the discussion.

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The Good, the Bad and the Ugly of the NIHSS: Time for a Change?

August 31, 2021
The NIHSS remains the fundamental assessment of stroke severity. However, some have called for modifying the NIHSS to better capture disability. Is it time to change the NIHSS?
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What Else Beyond the NIHSS Should We Be Doing Clinically?

August 24, 2021
The NIHSS was a research tool meant to limit variability and provide uniform quantifiable assessments  of stroke severity.  As the de facto standard for stroke exams and scores, it has withstood the test of time.  However, there is more to the assessment of acute stroke severity and this podcast takes a deep dive into what else we need to be doing besides the NIHSS.
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The Clock Is Dead - The Reign of Tissue Imaging

August 17, 2021
Mismatch is your friend if you want to treat acute stroke patients beyond 3 hrs. While the clock was once the king, tissue imaging may now define what brain is salvageable and what has been lost. Listen here and see if you agree that the clock is dead in stroke.
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Defining the SOC - Is 4.5 Hrs the Real Answer?

August 10, 2021
The standard of care can feel elusive. Listen here as Dr. Knight shares his expertise regarding the definition of the SOC in extended window therapy for tPA. It's not a simple question and Dr. Knight is the one to answer it.
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Aug 10

Defining the SOC - Is 4.5 Hrs the Real Answer?

Haemin posted on 8/10/2021

Moderator: Jordan Bonomo, MD, FCCM, FNCS
Other Participants: William A. Knight IV, MD, FACEP, FNCS

Defining the standard of care has broad implications for the health care decisions in a region. Understanding the SOC for tPA in the extended window is critical to being able to provide the best care to stroke patients. While it may seem simple to assume what the SCO is, defining it is far more challenging. World-wide, the SOC for tPA has been generally been accepted to include the 3-4.5 hr window from onset, however some controversy remains in the minds of many. Listen hear to learn about the nuances of defining the SOC in the extended window for tPA.

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