IV tPA for Acute Strokes in Patients with COVID - What Does the Limited Evidence Mean?

December 4, 2020
The incidence of acute stroke in COVID-19 patients occurs at a rate that is at least 7 times greater than the general population. Controversy about the safety and efficacy of IV-tPA remains.
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What Pitfalls Do Clinicians Face In Understanding Statistics In Acute Stroke Trials?

December 4, 2020
Statistics can illuminate or obfuscate. Clinicians need to understand acute stroke trial data and statistics in meaningful ways, but challenges abound.
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What Was Missing From the NINDS Trial?

December 4, 2020
The NINDS trial was the seminal study of IV-tPA in the treatment of acute stroke. Yet controversy still exists around the trial methodology and the interpretation of the data. Was anything missing from NINDS? Does it still resonate nearly 25 years later?
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When Might You Use Heparin in the NeuroICU for a Stroke Patient?

December 2, 2020
Heparin in stroke remains controversial. Understanding the history and data and essential to mastering stroke care.
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Are the NNT and NNH for tPA Useful or Misleading in Acute Stroke Care?

December 2, 2020
Stroke treatment data are hard to interpret and can be misleading. A lot of misinformation has made its way into the literature and has confounded acute stroke care. Understanding NNT and NNH can help clinicians understand risks and benefits in a meaningful way.
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